Interestingly, since it has been shown that targeted deletion of LepR in the adult Hip of mice is sufficient to induce depressive-like behaviors and alter the coping ability to stressful events [73], we hypothesize that the reduced activation of the LepR/JAK2/STAT3 pathway in ABA rats in the acute phase of the disorder might contribute to explain the increased anxiety and depressive-like phenotype observed in rats exposed to the combination of reduced energy intake and intense wheel activity [74,75]. The gene discussed is STAT3; the disease is Anxiety.