Previous researchers have explored the therapeutic effects and molecular mechanisms of DFV in a mice depression model in vivo and found that DFV alleviates depression-like behavior in mice by regulating the PI3K/Akt/mTOR-mediated brain-derived neurotrophic factor and tropomyosin-related kinase B signaling pathway [30,31]. This evidence concerns the gene NTRK2 and major depressive disorder.