Genes such as sirtuin-1 (SIRT1), C-reactive protein (CRP), C-X-C motif chemokine receptor 2 gene (CXCR2), as well as chemokines and interleukins such as interleukin 12 (IL12A) and C-X-C motif chemokine ligand 8 (CXCL8), are strongly associated with insulin resistance and T2D [17,18]. The gene discussed is SIRT1; the disease is Insulin resistance.