Further analyses of a second sample group of people with MetS (n = 279) and controls (n = 397) revealed significant associations between MetS and polymorphic loci in the CRP (rs2794521), ADCY3 (rs17799872), GHRL (rs696217), CDKAL1 (rs9295474), BDNF (rs11030107), CHRM4 (rs2067482), CHRM1 (rs2067477), HTR3A (rs1062613), and AKT1 (rs3803300) genes (Table 2). The gene discussed is CHRM4; the disease is metabolic syndrome.