Further analyses of a second sample group of people with MetS (n = 279) and controls (n = 397) revealed significant associations between MetS and polymorphic loci in the CRP (rs2794521), ADCY3 (rs17799872), GHRL (rs696217), CDKAL1 (rs9295474), BDNF (rs11030107), CHRM4 (rs2067482), CHRM1 (rs2067477), HTR3A (rs1062613), and AKT1 (rs3803300) genes (Table 2). The gene discussed is HTR3A; the disease is metabolic syndrome.