When all 1375 participants were considered, a multivariable linear regression analysis revealed an inverse association between homocysteine and 25(OH)D levels after adjusting for age, sex, BMI, waist circumference, SBP, DBP, smoking, alcohol, exercise, hypertension, diabetes mellitus, dyslipidemia, fasting glucose, HbA1c, triglycerides, HDL-cholesterol, LDL-cholesterol, creatinine, uric acid, hs-CRP, and TSH (β = −0.033, p < 0.001) (Table 3). The gene discussed is CRP; the disease is Hypertension.