At an IC50 of 92 g/mL, mitochondria-mediated apoptosis in triple-negative breast cancer cells (MDA-MB-231) could be induced by dysregulated Bax/Bcl2 expression and simultaneous disruption of mitochondrial membrane potential (ΔΨm), a novel fraction of proteins isolated from WS-roots, under conditions of high levels of reactive oxygen species (ROS). The gene discussed is BCL2; the disease is triple-negative breast carcinoma.