Further, we recommend the application of methanol as an excellent solvent for the extraction of bioactive metabolites in WS, to optimize regulatory benefits in the activities of cyclooxygenase-2, caspase-9, 5-Lipoxygenase, B-cell lymphoma-extra-large, and B-cell lymphoma 2. Here, PTGS2 is linked to B-cell non-Hodgkin lymphoma.