For example, AMPK signaling, which can act as an energy sensor by promoting fatty acid oxidation and inhibiting gluconeogenesis and fatty acid synthesis [38,39], and which can improve insulin signaling via stimulating the Nrf2 phosphorylation and, subsequently, the activation of GPx4 [40], was significantly enhanced in the HF mice with the CLA supplementation. This evidence concerns the gene GPX4 and hydrops fetalis.