In the present study, we noted that the infiltration of proinflammatory F4/80+ macrophages and the expression of genes as well as the proteins related to inflammation were both reduced, whereas the expression of glucose transporter (GLUT) and phosphorylation of AKT, which are key regulators of insulin signaling involved in the suppression of IR [32], were substantially enhanced in the adipose and liver tissues of the HF mice with the supplementation of CLA. Here, AKT1 is linked to hydrops fetalis.