SOD1 and colorectal carcinoma: Specifically, in the control rats, a significantly lower TAS was observed in the OBG_1 group compared to the OBG_0 group, as shown in Figure 4B. There was also a significant increase in the activity of antioxidant defense enzymes (GPx and SOD) in CRC animals fed with feed without OGB compared to control animals fed the same feed (p < 0.0001).