In addition, BPA acts through linking NRs such as ERs, AR, and/or membrane receptors such as the G protein-coupled estrogen receptor (GPER), resulting in activation of MAPK and PI3K/AKT pathways, promoting the transcription of mRNA of proinflammatory mediators such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor a (TNFa), all reported as basic predecessors of inflammation linked to metabolic syndrome [34]. The gene discussed is TNF; the disease is metabolic syndrome.