Focusing on NRs that directly affect lipid metabolism in the liver (Figure 1), the pregnane X receptor (PXR), the liver X receptor (LXR), and the aryl hydrocarbon receptor (AhR) promote lipogenesis, whereas proliferator-activated receptors (PPARs) and thyroid receptors inhibit hepatic steatosis and promote VLDL secretion [4,32]. The gene discussed is NR1I2; the disease is fatty liver disease.