To investigate the molecular mechanisms by which Vit C exerts its anti-inflammatory and neuroprotective effects, in this study, we examined the involvement of GSK3β after Vit C treatment both in a MPTP mouse model of PD and in an in vitro cellular model of neuroinflammation, represented by LPS-activated BV-2 microglial cells. Here, GSK3B is linked to Parkinson disease.