Thus, to evaluate whether L. acidophilus LA5 would also impact periodontitis associated with A. actinomycetemcomitans, such as MIP periodontitis, we tested its effect in an A. actinomycetemcomitans and S. gordonii periodontitis experimental model by evaluating the alveolar bone loss, expression of inflammatory mediators and pathogens’ recognition patterns in the gingiva, as well as the oral and gut microbiomes. The gene discussed is MIP; the disease is periodontitis.