STX2 and hemolytic-uremic syndrome: Similarly, through a comprehensive survey of 29,945 human STEC infections in the European Union from 2012–2017, Panel et al. [33] found that stx2a, stx2b, stx2c, and stx2f were the top four Stx2 subtypes represented, contributing to more than 90% of the severe clinical cases (i.e., HUS, bloody diarrhea, etc.)requiring hospitalization.