The importance of the CXCL10 and CXCL11 concentration gradient between CSF and serum as a biological mechanism that is responsible for the recruitment of CXCR3-expressing T-cells as principal mediators of local antiviral response into the CNS of TBE patients was first proposed by our group in 2007 [21]. Here, CXCL10 is linked to tick-borne encephalitis.