Furthermore, a few studies reported that Chlorogenic acid has been found to reduce UA, Cr, BUN, AST, ALT, and LPS levels, inhibit XO, decrease mRNA expressions of IL-1β, TNF-α, and NOD-like receptors, promote mRNA expressions of tight junction genes in the colon, and inhibit the expressions of TLR4, MyD88, and NF-κB signaling pathways in the kidneys of hyperuricemia mice [46]. The gene discussed is TLR4; the disease is hyperuricemia.