Qi et al. documented that PEW and LLW protein peptides lowered UA levels, suppressed ADA activity, inhibited hepatic and serum XOD, enhanced the expression of GLUT9, URAT1, ABCG2, OAT1, and OAT3, protected against kidney damage, and improved gut microbiota in a mouse model of hyperuricemia [78]. This evidence concerns the gene SLC22A12 and hyperuricemia.