KEGG pathway analysis represented that metabolite downregulated various pathways i.e., cytokines–cytokines receptor interaction, glycine, serine and threonine metabolism, Alanine aspartate and glutamate metabolism, NOD-like receptor pathway, RIG-1-like receptor pathway, AGE-RAGE signaling pathway, IL-17 signaling pathway, glutathione metabolism, lipid and atherosclerosis, alcoholism, neutrophil extracellular trap formation pathways, and systemic lupus erythematosus were significantly enriched (Figure 5F). Here, IL17A is linked to alcohol dependence.