CLEC4D and Insulin resistance: The data showed that the upregulated probiotics were substantially enriched in insulin resistance, steroid hormones biosynthesis, protein digestion and absorption, phospholipases D signaling pathway, retinol metabolism, linoleic acid metabolism, AGE-RAGE signaling pathway, PI3K/Akt signaling pathway, MAPK signaling pathway, TNF signaling pathway, and C-type lectin receptor signaling pathway (Figure 5G).