JUN and obesity due to melanocortin 4 receptor deficiency: Meanwhile, nine anti-obesity central targets, i.e., EGFR, ESK3B, PPARG, HSP90AA1, STAT3, MTOR, IL2, JUN, and JAK2 were screened using MNC, MCC, DC, and CC in the CytoHubba network tool (Figure 7a), and these central targets are selected for molecular docking later [36].