These findings suggest that the major saponins of PG can play a direct role in central anti-obesity targets, such as EGFR, ESK3B, PPARG, HSP90AA1, STAT3, MTOR, IL2, JUN, and JAK2, which are related to signaling pathway in molecular docking. This evidence concerns the gene STAT3 and obesity due to melanocortin 4 receptor deficiency.