This study chose to demonstrate the binding of dimethyl 2-O-methyl-3-O-a-D-glucopyranosyl platycogenate A and IL2, prosapogenin D and STAT3, 3′′-O-acetylplatyconic acid A and PPARG, platycodin A and EGFR, platycodin D2 and HSP90AA1, deapioplatycoside E and GSK3B, platycodin D3 and JAK2, deapio-platycodin D3 and JUN, platycodin C and MTOR, and platycodin D and EGFR in the 3D and 2D results of the ten pairings containing all selected saponins and central anti-obesity targets to illustrate the rationale for this study. Here, GSK3B is linked to obesity due to melanocortin 4 receptor deficiency.