NEFL and amyotrophic lateral sclerosis: The pooled mean sensitivity, specificity, and SROC curve for CSF NfL in distinguishing ALS patients from disease mimics were 0.87 (95% CI, 0.83 to 0.89), 0.84 (95% CI, 0.77 to 0.88), and 0.92, respectively (I2 = 69.4%; Figure 2C).