Genes that have been previously reported to be associated with ageing and neurodegenerative disease, such as BDNF (h2 = 0.27; FDR = 0.037) and FOXO3 (h2 = 0.31; FDR = 0.024), showed low but still significant heritability in the OATS sample, whereas Wright et al. [7] reported no significant heritability for the BDNF gene, although FOXO3 showed significant heritability. This evidence concerns the gene FOXO3 and neurodegenerative disease.