Q. Haolong et al. found that the smoking carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) decreased the expression of EGFR-AS1 in the long term but increased the expression of HIF2A and FOXP3 to stimulate lung cancer cell stemness. Here, FOXP3 is linked to lung carcinoma.