Inactivating mutations in FOXP3 lead to severe autoimmunity with a scurfy phenotype in mice and Immunodysregulation Polyendocrinopathy Enteropathy X-linked (IPEX) syndrome in humans, which is manifested by immune dysregulation, polyendocrinopathy and enteropathy [4,5]. This evidence concerns the gene FOXP3 and Autoimmunity.