Recently, it was suggested that TLR4 was associated with POAG for its activation generates meshwork fibrosis via the TGF-β pathway, leading to elevation of IOP [114]; in addition, ligands of TLR4 (e.g., LPS and HSP) were considered as candidate antigens of NTG [115]. The gene discussed is HSP90B2P; the disease is open-angle glaucoma.