OPTN and open-angle glaucoma: Mutations of OPTN have been widely considered a pathogenesis of POAG [98] as well as NTG [99,100], of which E50K (c.148G>A) is the most common to be associated with POAG, and another mutation H486R (c.1457A>G) is correlated with juvenile open-angle glaucoma (JOAG).