MALAT1 and hepatocellular carcinoma: On the other hand, many studies have indicated the role of MALAT1 in the resistance of cancer cells to chemotherapy in chronic myeloid leukemia, head and neck squamous cell carcinoma, and hepatocellular carcinoma [58], increasing the ability to repair DNA, evade cell cycle checkpoints, and regulate apoptosis, autophagy, and stemness of cancer cells.