In hepatocellular carcinoma (HCC), Huang et al. [31] observed that the expression of transcription factors Sp1 and Sp3 correlated with MALAT1 expression, and the co-silencing of both TFs repressed transcription of this lncRNA, which highlights the positive regulation of MALAT1 expression by these transcription factors. This evidence concerns the gene SP3 and hepatocellular carcinoma.