Increased MALAT1 expression was demonstrated in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), and knockout of MALAT1 in AML was found to inhibit proliferation by arresting the cell cycle in the G0/G1 phase and promote apoptosis of cancer cells by increasing the expression of caspase-3, -8, and -9 proteins [58,72]. The gene discussed is CASP3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.