HLA-C and cancer: These were found to be significantly associated with pathways such as proteoglycans in cancer, the phosphatidylinositol signaling system, and the GnRH signaling pathway (Figure 6C), and were enriched in GO terms such as regulation of chromosome segregation, antigen processing and presentation of exogenous peptide antigens via MHC, positive regulation of cell division, the TAP complex, inositol-1, and 4,5-trisphosphate 5-phosphatase activity.