Our study suggested that TM6SF2 rs58542926 C>T, HSD17B13 rs9992651 G>A, and GCKR rs1260326 T>C polymorphisms are not associated with the presence or severity of hepatic steatosis and liver fibrosis in MASLD in the Egyptian population (all p > 0.05). The gene discussed is HSD17B13; the disease is fatty liver disease.