GWAS validates PNPLA3 rs738409 C>G, with significant contributions from TM6SF2 rs58542926 C>T, HSD17B13 rs9992651 G>A, and GCKR rs1260326 T>C, as a risk factor for the entire histological spectrum of NAFLD at genome-wide significance levels [18,36]. This evidence concerns the gene HSD17B13 and metabolic dysfunction-associated steatotic liver disease.