PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The first gene variant found to have a consistent genetic association with NAFLD was the patatin-like phospholipase domain containing 3 (PNPLA3 rs738409 C>G) [7], and this association has been replicated extensively [8,9,10,11,12,13,14,15,16,17,18,19].