As yet, studies on the association of PNPLA3 rs738409 C>G, TM6SF2 rs58542926 C>T, HSD17B13 rs9992651 G>A, and GCKR rs1260326 T>C with NAFLD in the Egyptian population are still limited. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.