A previous report [74] has shown that clozapine increased expression of genes for a number of adaptor and clathrin assembly proteins (AP2A2, AP2B1, AP180, CLINT1, HIP1, ITSN, and PICALM) in human neuroblastoma cell lines, potentially due to involvement of AP180, serotonin 1A, and lysophosphatidic acid receptor 2, indicating a similar mechanism being operational in the actions of clozapine and fluoxetine. This evidence concerns the gene AP2B1 and neuroblastoma.