A total of 11 out of 15 targeted genes, PLIN3, EDEM2, ECM1, SURF4, SEC14L5, DHRS11, LGALS9, ALDH18A1, SPTAN1, NXPE4 and FIZ1 of fs-cb-miRs, were found associated with the diseases like bovine respiratory disease, mastitis resistance, and Hyperprolinemia type II, etc. (Table 7). The gene discussed is EDEM2; the disease is mastitis.