KLHL31 and early-onset autosomal dominant Alzheimer disease: Here, the targeted genes like DNTT, PTPRE, CNRIP1, CLEC4G, LMTK2, PHKA1, and KLHL were found associated with diseases like Schrizophrenia, Asthma, Colorectal Carcinoma, Liver Carcinoma, Glycogen Storage Disease, Chronic Lymphocytic Leukemia, Alcoholic Intoxication and Alzheimer diseases with a disease association type as a biomarker (Table 6).