In cattle, the targeted genes of fs-cb-miRs are involved in Apoptosis, Necroptosis, Chagas disease and Hepatitis C. Further, the gene–disease-association showed that mutation/variation in the genes like EDEM2, ECM1, SURF4, and DHRS11 caused bovine osteoporosis, bovine hereditary angioneurotic edema, mastitis resistance and bovine viral diarrhea in cattle. Here, ECM1 is linked to Chagas disease.