Few targeted genes of fs-cb-miRs like TNS1 (Cte-miR824-3p), UBE2K (Cte-miR168), FNDC3A (Cte-miR6183) and PAPD4 (Cte-miR7780-3p) were involved in malignant tumors of the breast, Alzheimer’s disease, Angelman syndrome and Hepatitis C virus infection, respectively. The gene discussed is UBE2K; the disease is early-onset autosomal dominant Alzheimer disease.