ECM1 and hereditary angioedema: In cattle, the targeted genes of fs-cb-miRs are involved in Apoptosis, Necroptosis, Chagas disease and Hepatitis C. Further, the gene–disease-association showed that mutation/variation in the genes like EDEM2, ECM1, SURF4, and DHRS11 caused bovine osteoporosis, bovine hereditary angioneurotic edema, mastitis resistance and bovine viral diarrhea in cattle.