Another study revealed that the four-gene biosignature (BATF2, UBE2L6, VAMP5, and SERPING1) is a robust blood-based diagnostic for active TB across seven datasets containing more than 1200 clinical samples and showed that the sensitivity or specificity can reach up to 100% (mean AUC = 0.86, sensitivity = 86%, and specificity = 81%) [61]. Here, SERPING1 is linked to tuberculosis.