SETBP1 and Global developmental delay: The SETBP1 gene is associated with several NDDs; in fact, haploinsufficiency due to deletions in the heterozygosity of the gene or mutations with the production of a nonfunctioning protein cause a dysfunction-related disorder of the SETBP1 gene, characterized by hypotonia and mild motor developmental delay; intellectual abilities ranging from normal to severely impaired; speech and language disorders; behavioural problems; and mild dysmorphic [37,38,39].