ASH1L and attention deficit-hyperactivity disorder: His features are consistent with individuals with previously reported ASH1L variants, including ID ((DP4 = 80; Shipley = 79) [27] and global adaptive (Vineland Adaptive Behavior Scales (VABS) = 76)) and speech delays (first words at 18 months) [28], febrile seizures beginning at age 3, ASD, attention deficit hyperactivity disorder (ADHD), obsessive behaviors, gastroesophageal reflux disease, and astigmatism.