As a result, we examined rare and common variants associated with ICS response for 12 regions previously associated with asthma and ICS response (DPP10, FBXL7, NDFIP1, TBXT, GLCCI1, HDAC9, TBXAS1, STAT6, GSDMB/ORMDL3, CRHR1, GNGT2, FCER2) in the PrecisionLink Biobank with replication in the Biorepository and Integrative Genomics (BIG) initiative. This evidence concerns the gene ORMDL3 and asthma.