TMEM106B and Alzheimer disease: Figure 5 illustrates the mean TMEM106B expression as it increases progressively from CU (10.76 ± 0.62 CPM; n = 74), to PSP (11.25 ± 0.43 CPM; n = 82), PA (12.13 ± 1.27 CPM; n = 30) and finally AD (13.10 ± 0.44 CPM; n = 80). TMEM106B mRNA levels are significantly higher in AD compared to CU (p = 0.002) and PSP (p = 0.003).