Duplication of Xq13.2-Xq21.31, the region containing YWHAZP8, along with other genes such as ATRX and PCDH11X, has been reported in a clinical case associated with X-inactivation, resulting in developmental delays and seizures in a boy with pubertal gynecomastia [51]. Here, PCDH11X is linked to Gynecomastia.