Use of YWHAZP5 as a biomarker of autoimmune thrombocytopenia, increased expression of YWHAZP2, YWHAZP3, and YWHAZP10 in the LPS-stimulated PBMC of systemic juvenile idiopathic arthritis patients, presence of YWHAZP3, YWHAZP4, and YWHAZP10 in synovial tissue macrophages from rheumatoid arthritis patients in disease remission, may suggest their involvement in maintaining immune status [55]. This evidence concerns the gene YWHAZP5 and rheumatoid arthritis.