TLR8 and systemic lupus erythematosus: Other studies verified the association of TLRs in the pathogenesis of SLE when they found that SNPs in TLR7, TLR8, and TLR9 increased SLE susceptibility in Asians [90,91], while SNPs in TLR3, TLR8, and TLR9 increased that in Danish subjects [92].