NOS3 and type 2 diabetes mellitus: Furthermore, Gualou Xiebai Banxia decoction has been found to protect against type II diabetes (T2DM) treatment with acute myocardial ischemia (AMI) (T2DM-AMI) by attenuating oxidative stress (OS) and apoptosis via phosphatidyl inositol 3-kinase (PI3K)/serine/threonine protein kinase B (Akt)/endothelial nitric oxide synthase (e-NOS) signaling [15].