For example, Bishop et al. assessed 220 cases of lung SqCC and found a prevalence of 24.5% of p16INK4a overexpression, considering a strong and diffuse nuclear and cytoplasmic staining present in ≥70% of the tumor as positive, while only 5% of cases were positive for HR-HPV by ISH [21]. The gene discussed is CDKN2A; the disease is neoplasm.