In agreement with that, Doxtader et al. reported a 35% positivity rate of p16INK4a in lung SqCC (considering a strong and diffuse nuclear and cytoplasmic staining present in ≥50% of the tumor as positive), where all cases were negative for HR-HPV [15], and similarly considering a strong and diffuse nuclear and cytoplasmic staining present in ≥70% of the tumor as positive, Chang et al. reported a strong diffuse expression of p16INK4a in 14.6% of NSCLC cases with negative results for HPV [43]. The gene discussed is CDKN2A; the disease is non-small cell lung carcinoma.