However, by dividing the cases according to the histological subtypes, a statistically significant association was found between p16INK4a expression and OS in SqCC cases, where cases with positive p16INK4a expression exhibited a better overall survival (p = 0.033) but not in ADC cases (p = 0.930) (Figure 2A–D). This evidence concerns the gene CDKN2A and AIDS dementia complex.