CDKN2A and metastatic malignant neoplasm in the lymph nodes: Further, poor OS and DFS were significantly associated with advanced pathological stages, positive lymph node metastasis, and tumor size >3 cm in p16INK4a negative cases, while, in p16INK4a-positive cases, only positive lymph node metastasis and advanced pathological stages were significantly associated with poor OS and DFS, respectively.