Namely, taking into consideration covariates that might contribute to CRC patients’ prognosis (age, sex, lifestyle habits, treatment, and tumor characteristic), GSTM1-null and GSTP1 IleVal+ValVal (variant) exhibited a significant prognostic effect in all assessed models, indicating a higher risk of mortality in carriers of these genotypes. This evidence concerns the gene GSTP1 and colorectal carcinoma.