In the multivariable logistic regression model, galectin-3 and disease duration were found to be independent predictors of exacerbations in COPD patients (OR = 5.322, 95% CI: 1.178–24.052, p = 0.03; and OR = 1.297, 95% CI: 1.028–1.635, p = 0.028, respectively). The gene discussed is LGALS3; the disease is chronic obstructive pulmonary disease.