The prevalence and impact of thrombophilia on recurrent pregnancy loss exhibit significant variability across studies, with Nahas et al. [42] reporting a significant prevalence of FVL (20.9%) and protein S deficiency (19.0%) among women with recurrent miscarriages, highlighting that Enoxaparin treatment increased live birth rates, especially for those with four or more miscarriages. Here, PROS1 is linked to thrombophilia.