Notably, Iordache et al. quantified the risk, revealing that the strongest independent risk factors for first-trimester losses were FVL and prothrombin (PT) compound mutations, with a 3-times-higher risk of miscarriage, followed by FVL homozygous mutation, with an OR of 3.66, and APS antibodies, which increased the risk of miscarriage by 4 times. Here, F5 is linked to autoimmune polyendocrinopathy.