As we previously found FGFb to be upregulated in a proteome profiler oncology array of etoposide-resistant RB cells s we hypothesized that inhibition of the FGFR might result in decreased PTPRE expression, whereas treatment with recombinant FGF (rFGF) possibly increases PTPRE expression. The gene discussed is PTPRE; the disease is retinoblastoma.