Moreover, the involvement of APOE in lipid metabolism, complement system regulation, neuroinflammation, blood–brain barrier integrity, oxidative stress, mitochondrial function, and angiogenesis contributing to Alzheimer’s or age-related macular degeneration pathogenesis [13,16,31] suggests multifaceted mechanisms through which APOE may contribute to the pathogenesis of PACG. Here, APOE is linked to age-related macular degeneration.