HIF1A and cancer: Cancer cells have a high need for glucose, and different genes involved in glycolysis are upregulated under HIF-1α transcriptional control: glucose transporters (GLUT1, GLUT3), lactate dehydrogenase (LDH), glycolytic enzymes hexokinase 1 and 2 (HK1, HK2), enolase 1 (ENO1), phosphoglycerate kinase 1 (PGK1), pyruvate kinase M2 (PKM2), etc. [233,234,235].