TP53 and Bloom syndrome: Some inherited genetic mutations are associated with an increased risk of developing OS, e.g., mutations of genes such as tumor suppressor p53 (P53) [4]; retinoblastoma protein (RB); ATP-dependent DNA helicase Q4 (RECQL4); Bloom syndrome, RecQ Helicase-Like (BLM); and Werner syndrome, RecQ Helicase-Like (WRN) [5,6,7,8].