HLA-DRB1 and autoimmune disease: In line with this, the alleles exclusively expressed in the vaccine-related cohort, although rarely and poorly associated with immune-related disorders, have been described to be predisposing risk factors for MS and other autoimmune diseases (HLA-DRB1*08 [64,65]) and IgG4 mediated encephalopathies and neuromyelitis optica (HLA-DRB1*10 [66,67,68,69]).