Searching the disease keywords “cleft palate” in the m6A Var database [60] showed that many recognized cleft palate susceptibility gene sequences have SNP changes that are converted into m6A modification sites, such as rs187379424 (G > A) of IRF6, rs886055457 of SUMO1 (T > C), and rs1058213 (G > A) of TGFα, etc., indicating that the m6A methylation modification level may change accordingly after SNPs occur in such genes. The gene discussed is IRF6; the disease is cleft palate.