In the key stage of palate development (E13.5–E15.5), compared to the control group, the METTL14 of the palatal mesenchyme was increased in the RA10D cleft palate group (p < 0.01), ki67 was significantly reduced (p < 0.001), and there was no significant difference in caspase 3 expression (Supplementary Figure S2D). The gene discussed is MKI67; the disease is cleft palate.