In the same Con-A murine model of AIH, anti-rhIL1R (an antibody against the IL1 receptor) protects mice from hepatitis by inhibiting the effects of IL-1β, such as immune cell infiltration and the activation of the NLRP3 inflammasome via the elimination of ROS production [66,68]. The gene discussed is NLRP3; the disease is hepatitis A virus infection.