Among the main causes of HCC from HCV infection is the activation of the phosphatidylinositol (PI3K)/protein kinase B (Akt)/mammalian target rapamycin (mTOR) pathway, which can be triggered by multiple damage-associated factors such as pro-inflammatory cytokines, TLR ligands, and growth factors [40]. Here, AKT1 is linked to hepatocellular carcinoma.