A study from Luan et al. showed that IL-1β, NLRP3, and caspase-1 are overexpressed in the liver of Concanavalin A (ConA)-induced AIH mice, while the absence of NLRP3 and caspase-1 reduces hepatocellular damage, thus protecting mice from hepatitis [66]. Here, IL1B is linked to hepatitis A virus infection.