NLRP3 and Hepatic steatosis: Zhang et al. exploited the P2X7R-NFLRP3 pathway as a target for treating alcohol-related liver steatosis, concluding that taxifolin (TAX), or dihydroquercetin, was able to lower the protein levels of cleaved caspase-1, NLRP3, and P2X7R, as well as IL-1β production, in alcohol-treated mice.