Consistent results were also found in murine models of MASH, since hepatic mRNA levels of caspase-1 and sera levels of IL-1β were abundant, while the suppression of NLRP3 was responsible for a decreased hepatic expression of this protein, along with a lowering of hepatic and circulating IL-1β, IL-6, and CCL2 [51,52] (Table 2). Here, IL1B is linked to metabolic dysfunction-associated steatohepatitis.