FGFR2 and cancer: Mutations have been additionally implicated in promoting breast tumorigenicity by maintaining breast tumor-initiating cells [17] as well as in gastric, lung, endometrial, colorectal, and pancreatic cancers and in the development of drug resistance highlighting the importance of FGFR2-TKD in malignant neoplasms [14,17,18,19,20,21,22].