For instance, the gene ID3 has been associated with various functional expressions (FXs) such as the movement of vascular endothelial cells, the ability of microvasculature to allow substances to pass through, and specific cellular CPs including PI3K/AKT signaling, atherosclerosis signaling, nitric oxide signaling in the cardiovascular system, and vascular endothelial growth factor (VEGF) signaling as shown in Figure 5B (Supplementary File S5). This evidence concerns the gene CAD and atherosclerosis.