TGFB2 and asthma: In addition, previously published literature has found how EVs can affect specific cells through intrinsic signaling pathways; for example, a study done by Salem et al. showed that EVs generated from bronchial fibroblasts could promote epithelial cell line remodeling through the TGF-β2 signaling pathway in severe asthma [49], suggesting that EVs are affecting the target cells’ intrinsic pathways and thus altering their function.