In their exquisite paper, Wang et al. [57] provided convincing evidence that SIRT1 (Sirtuin 1) downregulates miR-1185-1 levels in colorectal cancer cells by deacetylating its promoter, which results in enhanced expression of CD24, a target gene promoting colon cancer cell stemness. This evidence concerns the gene SIRT1 and malignant colon neoplasm.