FCER1A and Chronic Eosinophilic Leukemia, Not Otherwise Specified: Furthermore, AST was demonstrated to have anti-inflammatory properties and be able to suppress the generation of histamine in the human peripheral blood eosinophilic leukemia cell line KU812, which was caused by the cross-linking of high-affinity FcεRI (an IgE receptor) and anti-FcεRIα chain antibody CRA-1 [50] (Table 1).