CALCRL and colorectal carcinoma: At the level of the CRC stroma, CRLR reactions were identified in eosinophils, fibroblasts, some lymphocytes, macrophages, endothelial cells, and muscle fibers of medium caliber vessels, but also at the level of adipose tissue; the markers were also present in inflammatory intraepithelial mononuclear elements and enteroendocrine cells (Figure 3).