In this context, studies are needed to investigate not only descriptively, but also quantitatively, the significance of CRLR and CGRP reactions in inflammatory cells from the tumor stroma and from the level of the invasion front, and also from the level of the adjacent mucosa, especially since some studies indicate the association of postoperative complications for CRC with the composition and intensity of the inflammatory response [49]. Here, CALCRL is linked to neoplasm.