CALCA and neoplasm: We see that in the case of CGRP, the FSS is higher in patients with TNM III and IV, tumors invading adjacent organs (T4), metastases in more than three lymph nodes (N2), patients with distant metastases (M1), tumors with low differentiation grades (G3), a tumor budding score of 3, the presence of poorly differentiated clusters (PDC 1), the presence of vascular invasion (VI 1) and perineural invasion (PI 1), and with small higher difference in FSS in the case of mucinous tumors.