This shows us, as in the case of CGRP, the potential role of CRLR in the progression and invasiveness of colorectal adenocarcinomas, but that, unlike CGRP, the CRLR staining score cannot differentiate between tumors with perineural invasion and between mucinous/non-mucinous tumors. The gene discussed is CALCA; the disease is colorectal adenocarcinoma.