There was, however, a statistically significant increased frequency of MUC5B rs35705950 in RA-ILD, IPF, and CHP (which favor a UIP pattern) compared to ASyS-ILD (which favors an NSIP or OP pattern), suggesting these distinct phenotypes result from different genetic predispositions [26]. The gene discussed is MUC5B; the disease is idiopathic pulmonary fibrosis.