In innate immunity during viral infections, the binding of viral RNA to the helicase domains of retinoic-acid-inducible gene-1 and oligomerisation-domain-containing protein-like receptor-3 in myeloid cells activates the pro-inflammatory transcription factor nuclear factor (NF)-κB and the inflammasome [65,66,67], thereby inducing the release of CX3CL1 [65]. The gene discussed is CX3CL1; the disease is viral infectious disease.