CX3CR1 and viral infectious disease: Moreover, we review the accumulated evidence that the interactions of CX3CL1-CX3CR1 mediate significant events in viral infection, such as HIV, SARS-CoV-2, influenza virus, CMV, Dengue virus (DENV), ZIKA Virus (ZIKV), hepatitis B virus (HBV), viral infections, and associated diseases, especially through the recruitment of immune effector cells from the innate immune system via their chemotactic and adhesive properties.