Moreover, we review the accumulated evidence that the interactions of CX3CL1-CX3CR1 mediate significant events in viral infection, such as HIV, SARS-CoV-2, influenza virus, CMV, Dengue virus (DENV), ZIKA Virus (ZIKV), hepatitis B virus (HBV), viral infections, and associated diseases, especially through the recruitment of immune effector cells from the innate immune system via their chemotactic and adhesive properties. The gene discussed is CX3CL1; the disease is viral infectious disease.