CXCL8 and acute myeloid leukemia: Despite the mechanism leading to this vascular remodelling selectivity being currently unknown, emerging AML blasts were shown to directly promote angiogenesis by secreting VEGF and IL-8 soluble factors [180,181] or EVs enriched in several miRs, mRNA VEGF, VEFGR, and angiopoietins [24,25,77].