IL6 and acute myeloid leukemia: Despite both AML-EVs dosage induced BMMSCs to secrete known AML promoting cytokines, including IL-6, Gas-6, and Galectin-3, it would be interesting to determine whether this pleiotropic effect could be replicated in vivo (or in BM-mimetic ex vivo models) to ascertain whether it represents a common mechanism employed by LSCs in distinct stages of BM infiltration and disease burden.